NMN Supplement and Aging

By Dr. Sean Wells, DPT, PT, OCS, ATC/L, CSCS, NSCA-CPT, CNPT, Cert-DN

Nicotinamide mononucleotide (NMN) is a molecule that has gained attention in recent years due to its potential role in enhancing longevity and healthspan. Doctors of Physical Therapy (DPTs) ought to be aware of NMN as many clients have begun taking them and are unaware of new data and legal challenges ahead. NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in various cellular processes, including energy metabolism and DNA repair. Research on NMN supplementation in humans is ongoing, and while there is some promising evidence, it's important to note that the field is still evolving, and more research is needed to draw definitive conclusions.
Here is a research summary of NMN use in humans up to my knowledge cutoff date in September 2021:

1. NAD+ Levels: One of the primary reasons for interest in NMN is its potential to boost NAD+ levels in cells. NAD+ declines with age, and maintaining optimal levels is associated with various health benefits. Some studies have suggested that NMN supplementation can effectively raise NAD+ levels in humans, potentially mitigating age-related NAD+ decline.
2. Metabolic Health: Research has explored NMN's impact on metabolic health. Studies in mice have shown that NMN can improve insulin sensitivity, reduce fat accumulation, and enhance mitochondrial function. These findings have generated interest in NMN's potential as a metabolic health intervention in humans, particularly for conditions like type 2 diabetes and obesity.
3. Cardiovascular Health: There is preliminary evidence suggesting that NMN may have a positive impact on cardiovascular health. NMN has been shown to improve blood vessel function and reduce oxidative stress in animal studies. These effects could potentially benefit individuals at risk of cardiovascular diseases.
4. Aging and Longevity: NMN's role in extending lifespan and healthspan is an area of active research. Some animal studies have reported increased lifespan and improved health in mice with NMN supplementation. However, human trials on longevity are challenging to conduct due to the long time frames involved, and there are no definitive conclusions on this front as of 2021.
5. Safety and Tolerability: NMN has generally been considered safe and well-tolerated in the studies conducted on humans. Side effects have been minimal, with some reports of mild gastrointestinal issues. However, long-term safety data is limited, and more research is needed to assess any potential risks associated with prolonged use.
6. Cautions: It's important to note that while NMN shows promise, it is not a magic pill for aging or other health concerns. The science is still emerging, and there is no consensus on optimal dosages or long-term effects. Moreover, with robust results, a company has filed for the Food and Drug Administration to examine NMN as a drug; as such, companies selling the supplement have been in a legal limbo as to whether NMN is a supplement or a drug.

In summary, research on NMN's use in humans is ongoing, and early findings suggest potential benefits for metabolic health, cardiovascular health, and possibly aging-related processes. However, more rigorous and long-term studies are needed to establish its efficacy and safety conclusively. Individuals considering NMN supplementation should consult with healthcare professionals and be cautious about its use until more robust evidence is available. Given the current legal limbo, obtaining NMN may be tricky and further questionable as some legitimate supplements are steering clear away from the product. Hopefully we have more data and clarification soon so that physical therapists can educate their patients appropriately!

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Photo by Krzysztof Biernat: https://www.pexels.com/photo/shirtless-man-throwing-pills-out-of-a-bottle-15120890/

Keywords: nutrition, diet, continuing education, NMN, aging, supplement, PT, physical therapy, metabolism, rehab, DPT

Disclaimer: The above article is written as an opinion piece and does not convey specific legal, medical, and/or practice act advice.