Nightshade Controversy: Implications for Rheumatoid Arthritis Management

Rheumatoid arthritis (RA) is a complex autoimmune condition often accompanied by a myriad of symptoms. While dietary interventions can significantly impact disease management, the role of nightshade plants remains a topic of debate. A recent registration of a randomized clinical trial (RCT) looking at the role of nightshade plants and inflammation in those with RA will be exciting to read once finalized. Until then, let's look at these plants, how it impacts our PT patients, and how we should educate our clients.

Nightshades, which include tomatoes, potatoes, and peppers, have long been associated with increased inflammation. For individuals with RA, this association has raised concerns about potential exacerbation of symptoms. Part of the rationale for these plants causing inflammation is due to the solanine they contain. Solanine is a glycoalkaloid, a type of chemical compound that serves as a defense mechan...